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KMID : 0895820130230030087
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 3 p.87 ~ p.106
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The Review on the Randomized Controlled Clinical Trials of Bee Venom in the Journal of Korean Medicine
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Lee Yong-Seok
Lee Young-Jun
Han Chang-Hyun
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Abstract
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Objectives : We will provide basic information on bee venom clinical tests and aid the practical use of bee venom in such tests, through examination of RCT research related to bee venom that was reported domestically.
Methods : We collected 365 articles on Bee venom study result from the OASIS system using the Keyword ‘bee venom, apitoxin, apitherapy, bee sting’. The initially selected theses were primarily screened for clinical research. Out of these, case studies and non randomized controlled trial (non-RCT) were ruled out. As a result, 39 studies of randomized controlled trial (RCT) research were chosen as the subjects of study.
Results : RCT research related to bee venom was first presented in 2003, and 39 studies have been published until 2012. 18 studies were tests to confirm the effectiveness of bee venom, 7 studies were comparisons between SBV and BV, and 13 studies were comparisons with other types of treatment. Research conducted through appropriate randomization methods were 20 studies, and inappropriate randomization methods were used in 19 studies. In therms of Jadad score, 12 studies received 4~5 points, 15 studies received 1~3 points, and 12 studies received zero point.
Conclusions : In order to assure good quality RCT research, appropriate guidelines should be provided, and proper evaluation standards should be established. In-depth study is needed concerning the difference of responses to treatment according to the types of treatment received. A standardization of treatment should be reached as a result.
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KEYWORD
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Bee venom, Pharmacopuncture, Clinical trial, RCT
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